Anti-amyloid Alzheimer’s drugs show no clinically meaningful effect
People with Alzheimer’s disease have high levels of a protein known as amyloid beta in their brains, detectable before symptoms begin, but its role in disease progression is uncertain. Drugs…
Can a new heart health metric identify fracture risk in postmenopausal women?
Postmenopausal women face a high risk of bone fractures. Due to declines in estrogen levels, which can lead to an increased risk of osteoporosis, even a low-impact fall can result…
Nearly 30% of patients with resistant hypertension have a hormone disorder caused by high cortisol
Resistant hypertension is a condition where blood pressure stays high even though patients take three or more different blood pressure medications. This impacts nearly 10 million patients with high blood…
Targeted cholesterol-lowering therapy can prevent first heart attack or stroke in high-risk patients with diabetes
Mass General Brigham researchers found that the intensive cholesterol‑lowering therapy evolocumab reduced the risk of a first major cardiovascular event in high‑risk patients who did not have known atherosclerosis (the…
Thymidine Kinase 2 Deficiency (TK2d): European Commission approves doxecitine and doxribtimine (KYGEVVI®) as first and only treatment
UCB (Euronext Brussels: UCB), a global biopharmaceutical company, today announced that the European Commission (EC) has granted marketing authorization under exceptional circumstances for KYGEVVI (doxecitine and doxribtimine) for the treatment…
High-fat diets cause gut bacteria to enter brain
With more than 100 million neurons in the digestive tract, the gut is commonly known as the “second brain” in numerous cultures, including ancient Greece, Japan, China and India, linking…
Improving AI models’ ability to explain their predictions
In high-stakes settings like medical diagnostics, users often want to know what led a computer vision model to make a certain prediction, so they can determine whether to trust its…
Low testosterone, high fructose: A recipe for liver disaster
Low testosterone in itself can cause a variety of health problems, but the addition of a poor diet can exacerbate certain conditions. Metabolic dysfunction-associated steatotic liver disease (MASLD) is one…
First-ever in-utero stem cell therapy for fetal spina bifida repair is safe. The Lancet
A phase 1 clinical trial published in The Lancet has shown that combining stem cell therapy with standard fetal surgery before birth is a safe and promising approach to treat…
Exposing a hidden anchor for HIV replication
The tiny shell protecting the HIV virus resembles a slightly rounded ice cream cone, but there is nothing sweet about it. More than 40 million people worldwide live with AIDS…